EP29 PROGNOSTIC EFFECT OF ESTIMATED GLOMERULAR FILTRATION RATE IN PATIENTS UNDERGOING CARDIAC SURGERY

Abstract

Background: Chronic kidney disease (CKD) has been found to be an independent risk factor for cardiovascular diseases onset. We investigated the association between initial renal function and clinical outcomes in patients undergoing cardiac surgery. Methods: This was a single- centre, retrospective cohort study of 284 patients underwent cardiac surgery in Tor Vergata University Hospital between Genuary 2017 and February 2018. Patients with eGFR <60 ml/min (Group 1) were compered with patients with eGFR >60 ml/min. A propensity match score has been applied to investigate the effect of ultrafiltration in patients with eGFR <60 ml/min underwent cardiac surgery Results: No significant differences have been observed in term of cardiac, pulmonary, renal and cerebral complications between the two groups. In hospital mortality was 16% in Group 1 and 5.3% in Group 2 (p-value 0.003). In patients with eGFR < 60 ml/min, the propensity match score analysis did not reveal any significant differences in terms of morbidity between untrafiltered and no ultrafiltered patients. The ultrafiltration increased the risk of mortality (9%vs 2%, p-value 0.045). Conclusions: an initial eGFR< 60 ml/min is associated with an incremental risk of mortality in patients undergoing cardiac surgery. The extracorporeal circulation does not seem have any worsening effect on the renal function after the operation. No benefits have been observed using ultrafiltration in patients with severe renal failure.