Abstract
Obesity is a widespread disease globally, with an estimated 7% of cases representing childhood-onset disease associated with multiple comorbidities. Several genes have been implicated in the increased predisposition to syndromic and non-syndromic obesity. However, due to the genetic heterogeneity of early-onset obesity, the identification of pediatric patients with obesity that warrant a genetic evaluation poses a clinical challenge. Consequently, we have established an Endocrine-Genetics clinic with a multidisciplinary approach to evaluate pediatric patients with early-onset, severe obesity.
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