Abstract
Antenatal depression is associated with poor pregnancy and neonatal outcomes, as well as long term effects on offspring. Previous studies have identified links between antenatal depression and placental DNA methylation and between placental epigenetic aging and adverse pregnancy outcomes. It is possible that the relationship between antenatal depression and poor pregnancy outcomes is partly mediated via placental aging. We examined the relationship of antenatal depression in pregnancy with placental age acceleration (PAA), an epigenetic aging measure derived from the difference between DNA methylation age and chronological gestational age.
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