EP16.13: The correlation of nuchal translucency and maternal serum aneuploidy markers with placental dysfunction

Abstract

To evaluate the association of nuchal translucency (NT) at 11-13 weeks, maternal serum aneuploidy marker and placental dysfunction. The data were collected on 678 women delivered in single tertiary hospital between February 2011 and May 2016. NT and maternal serum aneuploidy markers during 1st and early 2nd trimester were measured respectively. Afterwards, pregnant women were subdivided into 4 groups: normal controls (487), pre-eclampsia (PE) group (74), intra-uterine growth restriction (IUGR) group (74) and PE with IUGR group (42). Statistical correlations between each of the parameters evaluated and incidence of placental dysfunction were investigated. PAPP-A was significantly lower in placental dysfunction groups than normal controls, and the lowest value was shown in PE with IUGR pregnancies (p<0.05). NT was elevated in IUGR and PE groups, but it was not statistically significant. Second trimester aneuploidy markers presented αFP and hCG were significantly higher in placental dysfunction groups than normal controls, while uE3 and inhibin-A were lower in these patients. The maternal serum aneuploidy markers were significantly associated with placental dysfunction disorder. However, these markers alone are not effective as screening methods due to low sensitivity and positive predictive value. Further research including uterine artery Doppler, additional serum markers and combination of such makers should be warranted.