EP16.03-038 Single-cell Analyses Reveal Tumor Microenvironment Differences between EGFR 19del and L858R mutations in Lung Adenocarcinoma

Abstract

Lung cancer is the leading cause of cancer-related mortality among malignant tumors worldwide. Lung adenocarcinoma (LUAD) accounts for 40% of all cases and is the most common histological subtype of non-small cell lung cancer (NSCLC). Activating somatic mutations, mostly identified as 19del and L858R in EGFR tyrosine kinase domain, may predict response to EGFR tyrosine kinase inhibitors (TKIs) in NSCLC patients. Although EGFR 19del and L858R patients are sensitive to TKIs, they showed different clinical benefits such as prolonged PFS in 19del patients.