Abstract
Lung cancer has the highest mortality rate of all cancers worldwide. Lung squamous cell carcinoma (LSCC) comprises a large fraction of non-small cell lung cancer (NSCLC), and annually accounts for 50,000 deaths in the US. Unlike lung adenocarcinoma, there is currently no first-line targeted therapy for LSCC. The PH domain and leucine-rich repeat protein phosphatase 2 (PHLPP2) has been reported to be a potent tumor suppressor in many human cancers. However, the underlying mechanisms by which PHLPP2 exerts tumor suppressive effects have not been fully investigated.
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