Abstract
Expression of Programmed Cell Death Ligand 1 (PD-L1) on tumour cells allows it to evade T-cell mediated killing, and therefore plays an important role in cancer progression. In non-small cell lung cancer (NSCLC) patients, the clinical efficacy of PD-1/PD-L1 inhibitor therapy is greatest in tumours with high PD-L1 expression. Additionally, atezolizumab (anti-PD-L1; Impower130 Trial) and pembrolizumab (anti-PD-1; Keynote-189) combined with cytotoxic chemotherapy has also demonstrated greater clinical efficacy than chemotherapy alone, even in patients with low-PD-L1 expressing tumours.
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