Abstract
Over the past years, the introduction of immune therapy in the treatment of lung cancer represented one of the most groundbreaking advances obtained in the cure of such deadly disease. In the field of immune-mediated therapies, Natural Killer (NK) cells represent an innovative cellular anti-tumor therapy and therapeutic target. Their cytotoxic activity is relevant to maintain immune surveillance in NSCLC patients, where the overall survival is positively related to NK cell infiltration. NK cytotoxicity is regulated through a wide range of receptors that allow them to rapidly respond to the absence of self molecules on target cells.
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