Abstract
EGFR mutations were classified into four subtypes (Classical-like, P-loop and αC-helical compressing (PACC), T790M-like, and exon 20 loop insertions) based on unique structures as Jacqulyne previously reported (Nature, 2021).Thus, EGFR mutant non-small cell lung cancer (NSCLC) should be considered as a heterogeneous disease. And there is clearly an unmet need understanding the biology trait of NSCLC with distinct EGFR mutation subtypes.
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