EP16.03-032 Structure-Based Classification of Chinese Patients with Non-Canonical EGFR-Mutant Non-Small Cell Lung Cancer

Abstract

Non-canonical EGFR mutations in non-small cell lung cancer (NSCLC) could be re-classified into four subtypes (Classical-like, P-loop and αC-helical compressing (PACC), T790M-like, and exon 20 loop insertions) based on unique structures as well as response to various types of tyrosine kinase inhibitors (TKIs). Since EGFR most frequently mutated in East-Asian population, it is clinically crucial to investigate the distribution of structure-based EGFR classification in Chinses NSCLC patients.