Abstract
Plasma next generation sequencing (NGS) is a non-invasive method for tumor genomic profiling that offers personalized treatment options via cell free DNA analysis for patients with advanced cancers. Targeted therapies direct activity toward specific functional protein domain(s) to inhibit tumor cell survival. The EGFR protein is comprised of an extracellular domain (ECD) that spans amino acids 1-620 and an intracellular tyrosine kinase domain (TKD) that can be targeted in multiple cancer types. In advanced non-small cell carcinoma (NSCLC), EGFR directed-therapies mainly focus on mutations within the TKD.
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