Abstract
Centrosomes are organelles that facilitate chromosome segregation. The number of centrosomes in a cell is tightly regulated to ensure the genome is divided equally during cell division. In normal cells, two centrosomes form a bipolar mitotic spindle for faithful chromosome segregation. Cancers often exhibit centrosome amplification (CA), an increase in centrosome number that can be caused by cellular insults such as cell cycle defects and carcinogen exposure. Cells with CA are prone to forming abnormal, multi-polar mitotic spindles which can induce aneuploidies that promote tumour progression.
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