Abstract
Neurotrophic tropomyosin-related kinases (NTRKs) A, B, and C constitute a receptor tyrosine kinase family involved in neuronal development. They are encoded by NTRK1-3 genes, respectively. NTRK fusions create chimeric genes in which the 3' region of the NTRK gene is joined with a 5' sequence of a fusion partner gene. As a result of the fusion, a chimeric oncoprotein originates a ligand-independent constitutive activation of the kinase activity. This chimeric kinase varies among tumor histology and population, being 0.3-3% in non-squamous NSCLC; however, little is known about these mutations among the Hispanic population.
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