EP16.03-001 High Frequency of KRAS Mutation, Uncommon EGFR Mutation and TMB-H in Xuanwei Female Patients With Lung Adenocarcinoma

Abstract

In female patients from Xuanwei county of China, the incidence and mortality of lung adenocarcinoma (LUAC) are extremely high, mainly due to abnormal exposure to carcinogenic polycyclic aromatic hydrocarbons produced during indoor combustion of bituminous coal. Thorough understanding of molecular features of Xuanwei female LUAC patients, when compared to reference Chinese female LUAC patients, could be beneficial to improve the management strategy for precision treatment in this high-risk population.