Abstract
High activity of Indoleamine 2,3-dioxygenase (IDO) in lung cancer patients converts tryptophan(Try), which is the essential amino acid for T cell metabolism, to kynurenine(Kyn) and consequently suppresses anti-tumor immune responses. We aimed to track the dynamic change of IDO activity in stage III non-small cell lung cancer (NSCLC) patients who received first-line radiotherapy and explore its association with survival outcomes.
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