Abstract
The nuclear export protein XPO1 (exportin 1) regulates the export of a range of cargoes from the nucleus to the cytoplasm and plays an important role in the maintenance of cellular homeostasis. XPO1 overexpression has been reported in multiple cancer types and can be associated with shorter progression free survival or overall survival (OS). However, the association and underlying mechanism for the relationship between XPO1 alterations and survival of non-small-cell lung cancer (NSCLC) patients remains unclear.
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