Abstract
Various peripheral immune cell populations have previously been implicated as potential biomarkers for response to immune checkpoint inhibition, although with inconsistent results between studies. The single-arm phase II trial SAKK 16/14 confirmed the efficacy of perioperative treatment with the andi-PD-L1 antibody durvalumab in patients with stage IIIA(N2) non-small cell lung cancer (NSCLC) with a clinically meaningful benefit compared to neoadjuvant chemotherapy alone. To evaluate the impact of treatment on the immune system, we comprehensively profiled immune cell populations derived from SAKK16/14 patients’ peripheral blood mononuclear cells (PBMCs) by mass cytometry.
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