Abstract
Lung adenocarcinoma in situ (AIS) has been reclassified as a glandular precursor lesion according to the latest fifth edition of the lung adenocarcinoma (LUAD) classification. This study was designed to investigate the immunophenotyping of AIS based on CD8-positive T cell infiltration and its changes in the progression progress to minimally invasive adenocarcinoma (MIA), then to invasive adenocarcinoma (IAC).
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