Abstract
Variants in PTPN11 are known to be associated with Noonan syndrome (NS), accounting for approximately 50% of cases. Data from a noninterventional and phase 3 study of Norditropin (somatropin; Novo Nordisk A/S, Denmark) were used to assess the impact of PTPN11 variant status on growth outcomes in children with NS receiving growth hormone therapy (GHT).
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