Abstract
The addition of programmed-death ligand 1 (PD-L1) inhibition with atezolizumab or durvalumab to platinum-doublet chemotherapy is the new standard treatment for extensive-stage small-cell lung cancer (ES-SCLC) as it improved survival in phase III trials, raising overall survival rate at 1 year (1-year OS) from 35% to about 50%. The vascular endothelial growth factor (VEGF) sustains angiogenesis and has immunosuppressive effects. The phase II SALUTE and the phase III FARM6PMFJM trial, the latter lead by our GOIRC group, have shown safety and provided signals of activity of bevacizumab, an anti-angiogenic agent, added to platinum doublet chemotherapy in patients with ES-SCLC.
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