EP14.24: Early and late fetal growth restriction: changes in fetal Doppler flow and correlation with pregnancy outcome in China

Abstract

The aims are(1) insight into the changes in fetal Doppler flow of early FGR and late FGR respectively by ultrasound evaluation;(2) to explore ultrasound predictor associated with pregnancy outcome. FGR was divided into early FGR (<32 weeks) and late FGR (>32 weeks) based on the time of onset. A total of 55 early FGR and 57 late FGR were recruited in our study with the normal controls established respectively. Ultrasound evaluation included fetal growth, umbilical artery (UA), heart rate (HR), fetal cardiac function (myocardial performance index, MPI and stroke volume, SV), ductus venosus (DV) and middle cerebral artery (MCA). Table1 was shown Fetal Doppler flow changes for early FGR and late FGR respectively. Perinatal morbidity and mortality rate for early FGR was 23/55 (41.8%) but it was only 4/63 (6.3%) for late FGR (P value<0.05). UA PI (OR=92.757), a wave velocity of DV (OR=0.958) and diastolic blood flow velocity of MCA (OR=1.363) were associated with early FGR pregnancy outcome by logistic regression. However, there was no fetal Doppler parameter but estimated fetal weight (OR=0.996) by ultrasound had relationship with late FGR pregnancy outcome. Early FGR is associated with a series of alterations in fetal Doppler flow. So once it is diagnosed, UA PI, a wave velocity of DV and diastolic blood flow velocity of MCA should be monitored comprehensively by ultrasound Doppler in order to improve pregnancy outcome based on the higher perinatal morbidity and mortality rate. However, late FGR has slight change on fetal Doppler flow, which tends to be good prognosis. As late FGR, estimated fetal weight by ultrasound is more important for pregnancy outcome than Doppler monitoring. EP14.24: Table 1. Fetal Doppler flow changes for early FGR and late FGR(All of P value <0.05) MCA PI CPR(Cerebroplacental) MPI systolic blood flow velocity of MCA