Abstract
In many neuroendocrine tumors, the vascular density (neuroendocrine main feature) is higher in the low-grade tumors than high-grade ones. This observation, so-called “neuroendocrine paradox”, gives to the angiogenesis a role as differentiation marker instead of prognostic marker. But the neoplastic angiogenesis is associated also with the oxidative stress. Thus, our goal is to verify if the oxidative stress could have a preeminent role in the lung NET compared with other neoplasms. Furthermore, we try to identify specific markers of oxidative stress in these tumors.
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