EP08.06: Clinical implementation of 5DCNS+ tool: prospective data of >1.100 consecutive pregnancies

Abstract

To evaluate reliability and diagnostic value of a semiautomised volumetric approach (5DCNS+) in terms of detailed assessment of the fetal CNS anatomy in normal and abnormal fetuses in a clinical setting. In this prospective study a total of 1.114 singleton pregnancies referred for targeted anatomic survey (including fetal neurosonogram) were enrolled. 3D volume data were acquired and post-processed using the 5DCNS+ software. All resliced volumes were categorised into 3 groups and scored in terms of adequately displayed diagnostic planes and the need for manual adjustment. In addition, 53 cases with major CNS anomalies were separately assessed and compared to matched controls. A total 1.093 cases met the inclusion criteria. Mean gestational age (GA) was 23.5 wks (16.6-36.7). By categorising into 3 groups (group I – GA >14 to 19.9 wks; group II 20.0 to 25.9 wks and group III ≥26.0 weeks) we were able to show that in group II the semiautomatic approach performed best (image reconstruction/adjustment; p=0.0003). Logistic regression model identified BMI and GA as dependent variables. Volume analysis using 5DCNS+ is feasible even in abnormal cases, although there were a significantly higher need for volume adjustment (p<0.001) and volumes to be acquired (p<0.001). In fact, the 5DCNS+ tool facilitates reliable assessment of fetal CNS anatomy even in case of altered cerebral anatomy. In 75 % of cases ≤ 2 manual adjustments were needed. In its present form it might rather be of value for diagnosis confirmation for professionals than for the inexperienced examiners. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.