Abstract
MET amplification (METamp) is a mechanism of acquired resistance to EGFR-TKIs. In INSIGHT (NCT01982955; data cut-off: September 3, 2021), the combination of tepotinib (a potent, highly selective MET-TKI) and the EGFR-TKI gefitinib (n=12) improved outcomes compared with chemotherapy (n=7) in patients with EGFR-mutant METamp NSCLC and EGFR-TKI resistance (progression-free survival hazard ratio [HR]=0.13, 90% confidence interval [CI]: 0.04, 0.43; overall survival HR=0.10, 90% CI: 0.02, 0.36). Tepotinib combined with an EGFR-TKI may therefore overcome MET-related EGFR-TKI resistance.
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