EP08.02-140 MET Biomarker-based Preliminary Efficacy Analysis in SAVANNAH: savolitinib+osimertinib in EGFRm NSCLC Post-Osimertinib

Abstract

Osimertinib, a 3rd-generation, irreversible, oral EGFR-TKI, is standard of care for patients with EGFRm NSCLC. Early data suggest that savolitinib, an oral, potent, and highly selective MET-TKI, in combination with osimertinib may overcome common acquired MET-based molecular resistance mechanisms following osimertinib monotherapy. The SAVANNAH (NCT03778229) study is investigating the efficacy and safety of targeted combination therapy with savolitinib+osimertinib, and exploring optimum MET detection methods and thresholds to identify patients most likely to respond.