Abstract
High-throughput phenotypic screening of large libraries of novel compounds without known targets can identify small molecules that elicit a desired cellular effect, but additional strategies are required to identify and characterize their targets and mechanisms of action. Here we characterize the novel small molecule LCS3, identified in a phenotypic screen of ∼190,000 compounds for its ability to selectively impair the proliferation of human lung adenocarcinoma (LUAD) cell lines, and investigate its mechanism of action.
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