Abstract
EGFR-targeted therapies have improved outcomes in patients with non-small cell lung cancer (NSCLC) harboring EGFR mutations, such as EGFR ex19del and L858R; however, resistance to these drugs is inevitable. BLU-945 is an investigational next-generation EGFR tyrosine kinase inhibitor (TKI) designed to suppress common activating and on-target resistance EGFR mutations, such as C797S and T790M. Preclinically it has shown activity as monotherapy in osimertinib-resistant patient-derived xenograft (PDX) models.
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