EP08.02-022 Investigating Partners in Crime: Osimertinib Resistance Mechanisms in Non-small Cell Lung Cancer Using Focused CRISPR Screen

Abstract

Non-small cell lung cancer (NSCLC) is the most prevalent and detrimental cancer type, accounting for 85% of all lung cancer cases. EGFR mutations, which can be targeted by tyrosine kinase inhibitors (TKIs), have been addressed as one of the cancer driving mechanisms in NSCLC adenocarcinomas. Osimertinib, a third generation EGFR-TKI, has been recently approved for clinical use in the first-line treatment of advanced NSCLC. Unfortunately, the long-standing obstacle in EGFR-TKI treatments, including Osimertinib, is the inevitable resistance.