Abstract
Pleural mesothelioma (PM) is a rapidly fatal tumor. The Cancer Genome Atlas (TCGA) investigation of PM revealed that patients with activated type-I interferon (IFN) pathway have a better clinical outcome. We recently demonstrated that the expression of endogenous retroviruses (ERV) due to promoter demethylation contributes to dsRNA formation and activation of type-I IFN signaling in an experimental mouse model of mesothelioma development. The aim of this study is to investigate ERV and type-I IFN activation in human PM.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Paper version not known
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
