Abstract
Interpretation of the clinical significance of somatic variants in cancer remains a major challenge in cancer diagnosis, prognosis and treatment response prediction. Here, we report on progress and plans of the Clinical Genome Resource (ClinGen) Somatic Cancer Clinical Domain Working Group (CDWG). The CDWG membership consists of over 150 multi-disciplinary experts in cancer biology, oncology, pathology, genetics, genomics, and informatics. The mission of the ClinGen Somatic Cancer CDWG is to facilitate the development of data curation guidelines and standards to determine the clinical significance of somatic alterations in cancer, thereby enhancing the usability, dissemination and implementation of cancer somatic variant interpretations in the ClinGen resource and other knowledgebases including the Clinical Interpretations of Variants in Cancer (CIViC), ClinVar, and the Variant Interpretation for Cancer Consortium (VICC) MetaKB.
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