Abstract
Increasing cardiac radiation dose is associated with worse survival and cardiac events following thoracic radiotherapy however, the mechanism of injury is unknown. High sensitivity cardiac troponin I (hsTnI) and N-terminal pro-B-type natriuretic peptide (NT pro-BNP) are established blood biomarkers of cardiac injury. Cardiac CT (CCT) is a non-invasive method of assessing coronary artery disease and echocardiography assesses cardiac structure and function. We present initial results of a prospective cohort study of cardiac blood and imaging biomarkers in patients undergoing lung cancer radiotherapy.
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