EP05.01-010 External Validation of Two Prediction Models for Severe Radiation-induced Lymphopenia during Concurrent Chemoradiotherapy for Lung Cancer

Abstract

Severe radiation-induced lymphopenia in patients undergoing chemoradiotherapy (CRT) for non-small cell lung cancer (NSCLC) is associated with detrimental survival outcomes and decreased efficacy of subsequent immunotherapy. This impact provides a strong incentive to identify patients at high risk who could benefit from lymphopenia-mitigating strategies. At The Christie, a prediction model for grade ≥3 lymphopenia was developed in lung cancer patients. At MDACC, a model for grade 4 lymphopenia was developed in esophageal cancer patients.