EP03.01-013 Improving the Risk Estimation for Second Primary Lung Cancer after Lung Cancer by Taking Histologic Subtype into Account

Abstract

Previous research has shown that lung cancer (LC) survivors are at increased risk for developing a second primary cancer (SPC) compared to the general population. While this risk is particularly high for smoking-related SPCs, the published standardized incidence ratio (SIR) for lung cancer after lung cancer are unexpectedly low (e.g. 0.83 and 2.06 for males and females in Germany [1]; 1.47 for both sexes in the UK [2]; 1.62 for both sexes in the United States [3]). These SIRs might be underestimated due to the histology-dependent documentation of SPC with the same location as the first cancer and differing definitions of SPC between International Agency for Research on Cancer (IARC) and US Surveillance, Epidemiology, and End Results (SEER) Program.This study aims to improve the estimation of SIR for second primary lung cancer (SPLC) in LC survivors by using histology-specific reference rates for estimating the expected number of SPLC.