EP03.14: Shear wave elastography in measurement of placenta in gestational diabetes mellitus

Abstract

To establish the normal reference range of elasticity in placenta, analysis its relationship with different gestational age and placental mature grading. To compare the difference between gestational diabetes mellitus and normal pregnancy in placental elasticity. Totally 168 normal singleton fetuses between 21and 40 gestational weeks were enrolled in this study, shear wave elastography was used to measure the placental elasticity, the mean, min and max of Young modulus were recorded. The correlation between all measurements and the gestational weeks or placental maturity grading was analysed. 20 fetuses collected randomly was examined by the same/different operator to analysed the repeatability/consistency reliability. 22 placentas of A1 gestational diabetes mellitus and 14 placentas of A2 gestational diabetes mellitus were assessed and compared with the normal. 1. In all healthy controls, placental elasticity had no relationship with gestational age and placental mature grading. 2. The repeatability/consistency reliability of the data obtained by the same /two different operator were good. 3. Young's modulus in normal placenta were 4.04±0.83 kPa (mean), 2.03±0.83 kPa (min) and 6.71±1.44 kPa (max), Young's modulus in A1 gestational diabetes mellitus placenta were 6.39±1.74 kPa (mean), 2.95±1.05 kPa(min) and 10.78±2.94 kPa (max), Young's modulus in A2 gestational diabetes mellitus placenta were 11.96±7.29 kPa (mean), 6.79±4.70 kPa (min) and 18.94±11.61 kPa (max), the interquartile range were 6.54-15.02kPa (mean), 2.58-10.97kPa (min) and 10.43-27.29kPa (max). The measurements of both A1 and A2 were higher than healthy controls (p<0.05) and the measurements of A2 were higher than those of A1 (p<0.05). Placental elasticity had no relationship with gestational age and placental mature grading; Shear wave elastography can be used to measure the elasticity of placenta in normal and gestational diabetes mellitus.