Abstract
Lung cancer (LC) is the leading cause of cancer related mortality. One reason is that still more than two thirds of patients are diagnosed with advanced disease. Cigarette smoking is the most important risk factor (RF). Recent LC screening studies demonstrated that annual low dose chest CT (LDCT) screening can reduce LC related mortality. Challenges still exist with LDCT based LC screening like optimal selection of individuals for LC screening programs, personalization of screening intervals, specification of individualized follow up intervals for nodule management or the detection of incidental findings
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