EP.WE.829Does Covid-19 increase the risk of gastrointestinal perforation? A preliminary UK-based multicentre cohort study

Abstract

Abstract Aims Recent case reports have described occult gastrointestinal perforation secondary to Covid-related microcirculatory thromboembolic phenomena. This study aims to evaluate the effect of Covid-19 on the incidence of gastrointestinal perforations across South West London (SWL). Methods A retrospective cohort study included all patients with gastrointestinal perforations presenting to three SWL-based NHS hospitals from 01/04/2020-31/12/2020 (i.e. “pandemic” cohort; from the first national lockdown), versus a representative “pre-pandemic” cohort (01/04/2019-31/12/2019). Data was extracted from the hospital coding records, patient case-notes, and the NELA database, and analysed by two independent clinicians. Results A total of 448 patients were included. 9.3% more (214 vs. 234, p = 0.286) gastrointestinal perforations presented during the pandemic period than beforehand. Comparing both periods, there were no significant differences between the numbers of colonic diverticular perforations (183 vs. 185), gastrojejunal ulcer perforations (1 per period), and terminal ileal perforations (1 per period). There were 78% more peptic ulcer perforations (9 vs. 16) and 55% more gallbladder perforations (20 vs. 31) during the pandemic period, although no overall significant difference was derived at the 95% confidence interval (Χ2=3.458, p = 0.484). Conclusions While there was no significant overall increase in spontaneous gastrointestinal perforation during Covid-19, this study clearly suggests increased rates of peptic and gallbladder perforations. Larger-scale epidemiological data are warranted to ascertain whether this is secondary to increased consumption of alcohol, non-steroidal anti-inflammatory medication or other pro-ulcerative drug regimes during the pandemic. Further data will also be vital to highlight delays in investigation and/or presentation resulting in these increased perforation rates.