EP.TH.63Predictive significance of tumour size in patients undergoing curative surgery for colorectal cancers: Retrospective cohort study

Abstract

Abstract Aims Evaluating predictive significance of tumour size in patients undergoing curative colorectal cancer surgery. Methods Patients undergoing curative surgery (77.6% Laparoscopic) for colorectal cancer by a single surgeon between January 2013 and January 2020 inclusive. Linear/binary logistic regression analyses were modelled to assess whether colonic or rectal tumour size could predict R0 resection, specimen length, length >120mm, number of harvested lymph nodes, >12 harvested lymph nodes, number of positive lymph nodes, lymphocytic infiltration, venous invasion, and overall survival. Results Total of 192 patients (124 colon and 68 rectal cancers) were eligible. In colon cancer patients, tumour size was independent predictor of the number of harvested lymph nodes (P < 0.001), the number of positive lymph nodes (P = 0.001), and lymphocytic infiltration (P = 0.009). It did not predict R0 resection (P = 0.563), specimen length (P = 0.111), specimen length >120mm (P = 0.186), >12 harvested lymph nodes (P = 0.145), venous invasion (P = 0.103), 5-year overall survival (P = 0.543). Independent predictor in rectal cancers was the number of harvested lymph nodes (P < 0.001), and the number of positive lymph nodes (P < 0.001). It did not predict R0 resection (P = 0.108), specimen length (P = 0.774), specimen length >120mm (P = 0.405), >12 harvested lymph nodes (P = 0.069), lymphocytic infiltration (P = 0.912), venous invasion (P = 0.105), and 5-year overall survival (P = 0.413). Conclusions Current study results suggest tumour size alone may not have a significant predictive value in terms of oncological or survival outcomes in patients undergoing curative surgery for cancer of colon or rectum.