Abstract
Galang et al (Circ Res 2020;127:1502, PMID 33044128) tested the epigenetic profile of cardiac pacemaker cells (PCs) using comparative ATAC-seq on the sorted neonatal mouse sinoatrial node (SAN) as compared with right atrial cardiomyocytes. PC-enriched ATAC-seq peaks, representing candidate SAN regulatory elements, were located near established SAN genes and were enriched for distinct sets of transcription factor binding sites. The authors identified a 2.9-kb regulatory element at the Isl1 locus that was active specifically in the cardiac inflow at E8.5 and throughout later SAN development and maturation.
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