Abstract
Meyer et al (Circulation 2010;121:1286, PMID 20212280) administered high-frequency stimulation (200 Hz) during the myocardial refractory period with electrode catheters inside the coronary sinus in 20 sheep. The results showed that stimulation evoked a systolic left ventricular pressure increase without changes in sinus rate or PR interval. Likewise, the rate of systolic pressure development, rate of diastolic relaxation, slope of the end-systolic pressure–volume relationship, and cardiac output increased.
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