Abstract
Lazarte et al (J Am Coll Cardiol 2022;80:50, PMID 35772917) determined the frequency and contribution of rare LMNA variants to cardiomyopathy and arrhythmia risk in ambulatory adults, including 185,990 UK Biobank participants with whole-exome sequencing, using 30 in silico prediction tools. Overall, 1167 participants (0.63%) carried an LMNA variant and 15,079 (8.11%) had an arrhythmia or cardiomyopathy event during a median follow-up of 10.9 years. The LMNA score was associated with arrhythmia or cardiomyopathy, and the association was more significant when restricted to variants upstream of the nuclear localization signal.
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