Abstract
Choi et al (Science 2022;376:1006, PMID 35617386) developed bioresorbable pacemakers with demand pairing with external wired systems for control. The system uses a transient closed-loop system that combines a time-synchronized wireless network of skin-integrated devices with an advanced bioresorbable pacemaker to control cardiac rhythms, track cardiopulmonary status, and provide multihaptic feedback. The study provides a range of autonomous rate-adaptive cardiac pacing capabilities demonstrated in rat, canine, and human heart studies. The system can help circumvent the current temporary postoperative cardiac pacing technique that requires devices with percutaneous leads and external wired power and control systems that can introduce infection risks and limit patient mobility. The authors conclude that the present study help establish an engineering framework for closed-loop temporary electrotherapy using a wirelessly linked, body-integrated bioelectronic device.
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