Abstract
Pfeufer et al (Nat Med 2010;42:153, PMID 20062060) reported a meta-analysis of genome-wide association studies for PR interval from seven population-based European studies in the CHARGE Consortium (N = 28,517). They identified nine loci associated with PR interval at P <5 × 10–8. At the 3p22.2 locus, they observed two independent associations in the voltage-gated sodium channel genes SCN10A and SCN5A. Six of the loci were near cardiac developmental genes, including CAV1-CAV2, NKX2-5 (CSX1), SOX5, WNT11, MEIS1, and TBX5-TBX3, providing pathophysiologically interesting candidate genes. Five of the loci (SCN5A, SCN10A, NKX2-5, CAV1-CAV2, SOX5) were also associated with atrial fibrillation (N = 5,741 cases, P <.0056). These data suggest a role for common variation in ion channel and developmental genes in atrial and atrioventricular conduction as well as in susceptibility to atrial fibrillation.
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