Abstract
Structural and electrical remodeling play critical roles in the maintenance of atrial arrhythmias. Rommel et al (Circ Res 2018;123:550–563, PMID 29930145) sought to identify transcription factors and downstream target genes involved in atrial structural remodeling in atrial tissues from patients with permanent atrial fibrillation (AF). They identified the transcription factor ETV1 (E twenty-six variant 1) to be significantly upregulated in AF. Moreover, Etv1 expression was 5-fold higher in atria compared to ventricular tissues. Cardiac myocyte-specific overexpression of Etv1 in a mouse model resulted in severe atrial remodeling and atrial arrhythmias. Conversely, ablation of Etv1 protected against atrial remodeling after angiotensin II stimulation. The authors identified genes involved in Ca2+ handling and gap junction formation (Ryr2, Atp2a2, Jph2, Gja5), potassium channels (Kcnh2, Kcnk3), as well as genes implicated in AF (Tbx5) as part of the ETV1-driven gene regulatory network. The authors conclude that ETV1 is a critical transcription factor in atrial remodeling and arrhythmias.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
