Abstract
Levin et al (Nat Commun 2022;13:6914, PMID 36376295) performed a multi-ancestry genome-wide association study meta-analysis of all-cause heart failure including 115,150 cases and 1,550,331 controls and identified 47 risk loci. Multivariate genome-wide association studies were performed that integrate heart failure with related cardiac magnetic resonance imaging endophenotypes, identifying 61 risk loci. Colocalization, gene expression profiling, and Mendelian randomization provide convergent evidence for the roles of BCKDHA (a gene encoding for branched chain keto acid dehydrogenase E1 subunit alpha) and circulating branched-chain amino acids in heart failure and cardiac structure.
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