Abstract
The relationship between eosinophils/basophils and allergic sensitization is not clear in pediatric adenotonsillar hypertrophy (ATH). The objective of this study is to investigate the relationship between eosinophil/basophil counts and peripheral specific IgE levels, and identify the common allergens in children with ATH. We initially screened 1,031 consecutive children who underwent adenotonsillectomy in our department from June 2018 to June 2019, and finally included 676 children. The eosinophil count, basophil count, and levels of specific IgE were collected. Correlations between two quantitative variables were assessed using the Pearson or Spearman coefficient. Logistic regression analyses were performed to evaluate the odds ratios (ORs) for atopy after controlling for age, sex, vitamin D, BMI, and visiting season. Both the eosinophil and basophil counts in atopic participants were significantly higher compared to non-atopic participants. The eosinophil count correlated with the levels of IgE specific to all allergens, and eosinophilia was independently associated with all tested atopy allergens other than atopy to dander after multivariate adjustment. Additionally, the basophil count correlated with the IgE levels specific to A. alternate and food mix, and basophilia was still significantly associated with atopy to food mix after multivariable adjustment. Furthermore, among allergic participants, D. farinae was the most prevalent allergen, followed by food mix, D. pteronyssinus, and A. alternata. In conclusion, eosinophils were more relevant to allergic sensitization than basophils, with eosinophils being significantly associated with all tested atopy allergens apart from dander, and basophils being associated with atopy to food mix. Furthermore, D. farinae was the most prevalent allergen and may be indicative of desensitization therapy.
Highlights
As a major part of the Waldeyer’s ring, adenoids and tonsils play an important role in immune defense
The children with eosinophilia exhibited higher total allergen specific IgE (sIgE) scores than children without eosinophilia (5.71 ± 5.60 vs. 1.65 ± 3.04, P < 0.001), and the percentage of children who were positive for serum sIgE to at least one of the examined allergens was higher in the eosinophilia group compared to the non-eosinophilia group (82.7 vs. 38.9%, P < 0.001)
Our study results indicate that both eosinophils and basophils were independently associated with allergic sensitization in adenotonsillar hypertrophy (ATH) children, but eosinophils were more relevant than basophils after adjusting for multiple variables
Summary
As a major part of the Waldeyer’s ring, adenoids and tonsils play an important role in immune defense. Eosinophils, Basophils, and Allergy in ATH otolaryngologists [1] It is the most common reason for upper airway obstruction in children and can lead to a series of sequelae such as mouth breathing, obstructive sleep apnea, otitis, sinusitis, and craniofacial anomalies [2]. Papatziamos et al [5] demonstrated that IgE-positive plasma cells were found in the adenoids of atopic children, while non-atopic adenoids contained none or very few IgE-positive cells. All these reports indicate that there is a close relationship between allergies and ATH
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