Abstract
Eosinophilic Esophagitis (EoE) is an increasingly common inflammatory condition of the esophagus. Eosinophils are a defining feature of EoE histopathology yet their role(s) in this disease remains poorly understood. To explore the role of eosinophils in EoE we utilized a transgenic mouse model of EoE “EoE33” and crossed this model with an eosinophil-deficient mouse, ΔdblGATA. Eosinophils have been shown to produce type 2 cytokines thought to mediate pathology of EoE. We hypothesized that removal of eosinophils from EoE33 would result in reduced inflammation and remodeling.
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