Abstract
Objective The aim of this study was to describe the clinicopathologic features of 30 new cases of oral eosinophilic ulcers. Study Design Clinical data concerning sex, age, affected site, and clinical presentation of 30 patients from Latin America were collected from the files of 2 Oral Pathology Laboratories in a period between 1982 and 2018. Results The mean age of the patients was 53.3 years, with slight predilection for female patients (1.2:1). Medical history of one-third of patients included psychiatric disorders, alcohol drinking, diabetes mellitus, and human immunodeficiency virus (HIV) infection. The tongue was the most common affected site (76.7%) by lesions with mean size of 1.8 cm and mean evolution of 5.4 months. Raised edges, pain and clinical suspicion of squamous cell carcinoma (SCC) were reported in almost half of cases. Microscopically, all cases revealed a connective tissue covered by fibrinopurulent membrane, containing many capillaries with prominent endothelial cells and reactive inflammatory infiltrate. Variable number of eosinophils was observed, mainly located in the lamina propria, but also deeply between muscle fibers. Conclusions Eosinophilic ulcer is likely a reactive painful lesion that mainly affects the tongue of adults, which may clinically mimic oral SCC.
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