Eosinophilic syndrome with life-threatening end-organ damage

Abstract

Introduction: Hypereosinophilic syndrome (HEs) can be a multisystem disorder due to direct end-organ damage by eosinophilia, and can rarely present with life-threatening features. We present a case of multi-organ failure secondary to eosinophilia related to medications. case report: A 66-year-old woman with a recent diagnosis of asthma on montelukast, presented with excruciating pains of sudden onset in her lower limbs, and on admission, she was found to be in multi-organ failure. After initial resuscitation, immunological investigations, including vasculitic screen were negative, and hematological investigations revealed severe eosinophilia. she was diagnosed to have systemic eosinophilic granulomatosis polyarteritis secondary to montelukast. the agent was withdrawn and the patient was started on prednisolone. the initial symptom of severe pains preventing her from mobilizing was reversed within days and the patient was cured and become steroid free after six weeks of steroid treatment with no further problems reported in subsequent follow-up. conclusion: