Eosinophilic Granulomatosis with Polyangiitis and Atopy: A Case Report

Abstract

A 36-year-old male, diagnosed with atopic dermatitis and allergy to egg white when he was a baby, was diagnosed in adolescence with Bird-Egg Syndrome and seasonal rhinoconjunctivitis with bronchial asthma. Five years later, he developed rhinosinusitis, nasosinusal polyposis and persistent bronchial asthma. At the age of 27, this individual presented with eosinophilic esophagogastroduodenitis and peripheral eosinophilia with a total IgE of 1,989 KU/mL and repeatedly tested negative for antineutrophil cytoplasmic antibodies. When he was 31-year-old, the patient was admitted to the hospital due to an exacerbation of his asthma, the onset of fever, bilateral migratory lung infiltrates and maculopapular lesions in the ankles (leukocytoclastic vasculitis). He was also diagnosed with motor-sensory polyneuritis. Finally, this patient met the criteria of allergic granulomatosis with polyangiitis and was treated with Omalizumab (monthly) with effective recovery.