Eosinophilic folliculitis in association with chronic lymphocytic leukemia: A clinicopathologic series

Abstract

Well-recognized variants of eosinophilic folliculitis (EF), also known as eosinophilic pustular folliculitis, include Ofuji disease, infantile EF, and HIV-associated EF, which is considered a defining illness of AIDS. A fourth less commonly recognized subtype of EF is that associated with hematologic malignancy, in particular leukemia and non-Hodgkin lymphoma (NHL).1 EF in HIV-negative individuals and associated with hematologic malignancy was first reported in 1993.2 This variant of EF may be underrecognized and difficult to diagnose given the clinical scenario, morphology, and variable histologic findings, detailed in a series of 3 patients with EF in association with chronic lymphocytic leukemia (CLL) presented herein.